Modelling mitochondrial ROS production by the respiratory chain
نویسندگان
چکیده
منابع مشابه
Superoxide production by the mitochondrial respiratory chain.
Most of the oxygen consumed by aerobic organisms is reduced to water by the enzyme cytochrome c oxidase in the terminal reaction of the mitochondrial respiratory chain. Since oxygen in the ground state is in a triplet configuration (with two unpaired electrons in the outer shell) its reduction to water must occur in four consecutive one-electron steps. Some of the partially reduced oxygen inter...
متن کاملThe mitochondrial respiratory chain.
In the present chapter, the structures and mechanisms of the major components of mammalian mitochondrial respiratory chains are reviewed. Particular emphasis is placed on the four protein complexes and their cofactors that catalyse the electron transfer pathway between oxidation of NADH and succinate and the reduction of oxygen to water. Current ideas are reviewed of how these electron transfer...
متن کاملMitochondrial Bioenergetics and ROS Production
immersed in a medium containing 21% oxygen, a highly reactive molecule. Fortunately for us, this impediment to life has been turned back on itself and has actually been harnessed by the cell to generate the stored chemical energy necessary to meet the major demands of cell physiology. Mitochondria are the organelles providing this protection, compartmentalizing and controlling the oxidation of ...
متن کاملModulation of mitochondrial respiratory function and ROS production by novel benzopyran analogues.
A substantial body of evidence indicates that pharmacological activation of mitochondrial ATP-sensitive potassium channels (mKATP) in the heart is protective in conditions associated with ischemia/reperfusion injury. Several mechanisms have been postulated to be responsible for cardioprotection, including the modulation of mitochondrial respiratory function. The aim of the present study was to ...
متن کاملThe Aerobic Mitochondrial Respiratory Chain
INTRODUCTION Fumarate reductase (FRD) catalyses the reduction of fumarate to succinate and is a key enzyme for the anaerobic functioning of many organisms respiring with fumarate as terminal electron acceptor. The ability to reduce fumarate is a common property among Gram-negative bacteria and some facultative anaerobic Gram-positive bacteria. The reduction of fumarate is also important in the ...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2019
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-019-03381-1